Welcome to my homepage.

About Me

I go by the name Ravi. I work for the Advanced Biomedical Computing Center (ABCC) at the National Cancer Institute (NCI), NIH in Frederick, MD.

Some of the recent publications of mine are given below

1. Exploring Enantiospecific Ligand-Protein Interactions Using Cellular Membrane Affinity Chromatography: Chiral Recognition as a Dynamic Process, K. Jozwiak, R. Moaddel, S. Ravichandran, A. Plazinska, J. Kozak, S. Patel, R. Yamaguchi, I. Wainer J. of Chromatography B (Accepted 2008)
2. Neurocalcin-delta Modulation of ROS-GC1, A New Model of Ca2+ Signaling, V. Venkataraman, T. Duda, S. Ravichandran and R. K. Sharma, Biochemistry (In Press 2008)
3. Pharmacophore Modeling of Stereoselective Binding to the Human Organic Cation Transporter (hOCT1), Ruin Moaddel, S. Ravichandran, Federica Bighi, Rika Yamaguchi and Irving W. Wainer, British Journal of Pharmacology 151(8), 1305-14 2007
4. Interferon gamma: Ancestors kept their tradition, Ram Savan, S. Ravichandran, Jack R. Collins, Masahiro Sakai and Howard A. Young, (Submitted to Genes and Immunity 2007)
5. Interaction of Noncompetitive Inhibitors with an Immobilized α3β2 Nicotinic Acetylcholine Receptor Investigated by Affinity Chromatography and Molecular Docking, Krzysztof Jozwiak, S. Ravichandran, Jack R. Collins, Ruin Moaddel and Irving W. Wainer, Journal of Medicinal Chemistry, 50(24), 6279-6283 2007
6. Computer Simulated Screening of Dentin Bonding Primer Monomers through Analysis of their Chemical Functions and their Spatial 3-D Alignment, J. Vaidyanathan, T. K. Vaidyanathan, and S.Ravichandran, Journal of Biomedical Materials Research Part B: Applied Biomaterials , 2007 (Accepted).
7. Computational analysis of adhesion of primer ligands to dentinal Collagen: Effect of Spacer groups in ligand and amino acid residue sequence differences in collagen J. Vaidyanathan, S. Ravichandran and T. K. Vaidyanathan, Current Drug Discovery Technologies, Volume 4(3), 150-161, 2007.

To see the complete list of publications, abstracts, and the list of talks, click here

Recent Scientific Meetings/Talks

1. The Chemistry and Biology of Cancer, Jack R. Collins, S.Ravichandran and Brian R. Luke, Student Professional Development Conference, Sponsered by Frederick County Business Rountable for Education, May 29, 2008. (Multiple session of Lecture/hands-on sessions to FCPS 10th grade students)
2. The Chemistry and Biology of Cancer, Jack R. Collins, S.Ravichandran and Brian R. Luke, Tuscarora High School, FCPS, Frederick June 10, 2008 (Lecture/hands-on session 10th grade students).
3. Pharmacophore Modeling in Two Different Systems: Understanding Stereoselective Binding in hOCT1 and Primer Adhesion in Dentinal Collagen S. Ravichandran, Accelrys Science Forum, Princeton, NJ (25 Oct, 2007)
4. Phrmacophore Modeling of Stereoselective Inhibitor Binding Site of the hOCT1, S.Ravichandran, R. Moaddel, F. Bighi, J.R. Collins, R. Yamaguchi, I.W. Wainer, Presented in the 51st Biophysical Society Annual Meeting, March 3-7, Baltimore 2007
5. Understanding Dentinal Adhesion using Common Features (HipHop) Hypothesis Approach: An Active Analog Approach, Catalyst User Group Meeting, J. Vaidyanathan, T.K. Vaidyanathan and S. Ravichandran, Sanofi-Aventis-Bridgewater, NJ Sep 2006
6. Genetic Algorithms as a Tool for Modeling Biomolecular Processes, S. Ravichandran , SOM Cell Biology Department, University of Medicine and Dentistry of NJ, Stratford, NJ, Jan 2006

Patent

• Computer based model for identification and characterization of non-competitive inhibitors of nicotinic acetylcholine receptor, Irving W. Wainer, Krzysztof Jozwiak, S. Ravichandran, Jack R. Collins, 2003

Model(s) that I co-authored

• 1T53: ATP regulated module (ARM) domain of the Natriuretic Factor Receptor Guanylate Cyclase
• 2ASG: Luminal domain of the α3β4 subtype of nicotinic acetylcholine receptor

Classes

List of classes I am teaching at the Advanced Biomedical Computing Center, National Cancer Institute (NCI), Frederick, MD. To see a complete list of classes I had taught in NCI, click here

1. Introduction to Molecular Modeling and Computer Simulation: Go to http://ncisgi.ncifcrf.gov/~ravichas/MM
2. Homology Modeling, To view the class notes, go to http://ncisgi.ncifcrf.gov/~ravichas/HomMod
3. Protein-Ligand Docking, To view the class notes, go to http://ncisgi.ncifcrf.gov/~ravichas/docking
4. Quantitative Structure-Activity Relationships (QSAR), To view the class notes, visit the following web-link http://ncisgi.ncifcrf.gov/~ravichas/QSAR/.

Software

• ABCC users (NCI and NIH only) can now carry out 3D-database searches using Discovery Studio 2.0 sofware. To learn more about this, click here.
• Discovery Studio/Materials Studio in ABCC. Click here for details.
• Pharmacophore Modeing: Instructions on how to run Catalyst CATALYST (Accelrys Inc.) in ABCC.
• Virtual docking using AutoDock in ABCC. Click here to learn about this.
• Click here for instructions on running GROMACS in ABCC Linux cluster.
• Statistical Software, R, in ABCC: Click here for instructions on using R in ABCC.

Other Areas of Interest

Programming Using Fortran

1. G95 :A free stable compiler for multiple CPU architectures and OS
2. Fortran-2000
3. Technical Recipes
4. Liens Fortran
5. John Burkardt: Very Good Fortran Code Collection
6. Dennis Foley: My Friend/Mentor's webpage

Useful web-links

1. NCI-Frederick Library
2. PubMed--Entry web link
3. Protein Data Bank (RCSB)
4. Computational Chemistry List
5. Chemistry University of Maine Chemistry website with Quizzes and animations
6. FDA Drug Information
7. Statistics: The Little Handbook of Statistical Practice

S. Ravichandran, Ph.D. 
Scientist
Advanced Biomedical Computing Center 
Bldg 430, Room 227 
National Cancer Institute 
Frederick, MD 21702 
Email: sravi at ncifcrf dot gov
Web: http://ncisgi.ncifcrf.gov/~ravichas 
Voice:   301-846-1991 
Fax:     301-846-5762